No subject
Thu Jan 31 12:10:26 EST 2008
"reading a microarray typically requires a high-resolution
digital fluorescence microscope, which is very expensive"
=20
=20
OLPC could be connected to USB chip for fast/cheap diagnostics.
=20
http://www.ece.ualberta.ca/~chrisb/research/lifesciencemain.htm
January 29, 2008
Genetic testing Lab on a chip for less than $100 Canadian <http://nextbig=
future.com/2008/01/genetic-testing-lab-on-chip-for-100.html> =20
Since a journal article was submitted to the Royal Society of Chemistry, =
the U of Alberta researchers have already made the processor and unit sma=
ller and have brought the cost of building a portable unit for genetic te=
sting down to about $100 Cdn. <http://www.eurekalert.org/pub_releases/200=
8-01/uoa-loa012808.php> In addition, these systems are also portable and=
even faster (they take only minutes). Backhouse, Elliott and McMullin ar=
e now demonstrating prototypes of a USB key-like system that may ultimate=
ly be as inexpensive as standard USB memory keys that are in common use -=
only tens of dollars. It could help with Pandemic disease control and de=
tecting and controlling tainted water supplies.
This development fits in with my belief that there should be widespread i=
nexpensive blood, biomarker and genetic tests <http://nextbigfuture.com/2=
007/11/proposal-for-widespread-monitoring-and_09.html> to help catch dis=
ease early and to develop an understanding of biomarker changes to track =
disease and aging development. We can also create adaptive clinical trial=
s to shorten the development and approval process for new medical procedu=
res <http://nextbigfuture.com/2007/12/biomarkers-and-adaptive-clinical-tr=
ials.html>=20
<http://farm3.static.flickr.com/2223/2229764522_94fe125b9e.jpg?v=3D0>=20=
The device is now much smaller than size of a shoe-box (USB stick size) w=
ith the optics and supporting electronics filling the space around the mi=
crochip
Canadian scientists have succeeded in building the least expensive porta=
ble device for rapid genetic testing ever made <http://www.rsc.org/Publis=
hing/ChemScience/Volume/2008/02/Genetic_testing_shoe-box.asp> . The cost =
of carrying out a single genetic test currently varies from hundreds to t=
housands of pounds, and the wait for results can take weeks. Now a group =
led by Christopher Backhouse <http://www.ece.ualberta.ca/~chrisb/> , Univ=
ersity of Alberta, Edmonton, have developed a reusable microchip-based sy=
stem that costs just 500 (pounds) to build, is small enough to be portabl=
e, and can be used for point-of-care medical testing.=20
=09
To keep costs down, 'instead of using the very expensive confocal optics=
systems currently used in these types of devices we used a consumer-grad=
e digital camera', Backhouse explained.=20
=09
The device can be adapted for used in many different genetic tests. 'By =
making small changes to the system you could test for a person's predispo=
sition to cancer, carry out pharmacogenetic tests for adverse drug reacti=
ons or even test for pathogens in a water supply,' said Backhouse.
The heart of the unit, the 'chip,' looks like a standard microscope slid=
e etched with fine silver and gold lines. That microfabricated chip appli=
es nano-biotechnologies within tiny volumes, sometimes working with only =
a few molecules of sample. Because of this highly integrated chip (contai=
ning microfluidics and microscale devices), the remainder of the system i=
s inexpensive ($1,000) and fast.
=09
There are many possible uses for such a portable genetic testing unit:=20=
=09
Backhouse notes that adverse drug reactions are a major problem in healt=
h care. By running a quick genetic test on a cancer patient, for example,=
doctors might pinpoint the type of cancer and determine the best drug an=
d correct dosage for the individual.=20
=09
Or health-care professionals can easily look for the genetic signature f=
or a virus or E. coli - also making it useful for testing water quality.=20=
=09
"From a public health point of view, it would be wonderful during an epi=
demic to be able to do a quick test on a patient when they walk into an e=
mergency room and be able to say, 'you have SARS, you need to go into tha=
t (isolation) room immediately.' "=20
=09
A family doctor might determine a person's genetic predisposition to an =
illness during an office visit and advise the patient on preventative lif=
estyle changes.
Henry Brown
henry.brown at state.nm.us
cell 795-3680
office 505 827-2509
________________________________
From: Brown, Henry, DoIT
Sent: Mon 1/28/2008 11:26 AM
To: Benjamin M. Schwartz
Subject: RE: [OLPC library] 'OLPC-Health' takes off !!- MATLAB for OLPC?
Cheap CMOS CCD technology used in digital cameras may be able replace mic=
roscopes in the near future.
http://www.genewave.com/documents/PS004-03_AmpliReaderW.pdf?PHPSESSID=3D1=
e778bdb95bb62afeb3343f27ff1b428
=20
We need a prototype for clinics in the field. How soon?
There is little economic incentive to develop this technology in developi=
ng markets.
However China and India are developing similar technology to cut health c=
osts.
http://www.sciencedaily.com/releases/2007/03/070330092822.htm
=20
Henry Brown
henry.brown at state.nm.us
cell 795-3680
office 505 827-2509
________________________________
From: Benjamin M. Schwartz [mailto:bmschwar at fas.harvard.edu]
Sent: Mon 1/28/2008 11:00 AM
To: Brown, Henry, DoIT
Cc: Arjun Sarwal; library at lists.laptop.org; devel at lists.laptop.org; ehong=
@mathworks.com; pbaca at sfccnm.edu; acpceo at yahoo.com
Subject: Re: [OLPC library] 'OLPC-Health' takes off !!- MATLAB for OLPC?
On Mon, 2008-01-28 at 08:34 -0700, Brown, Henry, DoIT wrote:
> Could Matlab create Greene Chip DNA microarray software to run on
> OLPC?
> http://www.mailman.hs.columbia.edu/news/Lipkin_GreeneChip.html
> http://www.mathworks.com/matlabcentral/fileexchange/loadFile.do?objectI=
d=3D2573
> http://laptop.org/
> http://www.sciencedaily.com/releases/2008/01/080121100909.htm
>=20
> If the MATLAB software could run on OLPC it could be used to monitor
> disease in the field.
> I worked with AIDS patients and child nutrition programs while in the
> Peace Corps.
> We saw kids die every week from RSV and dehydration caused by
> diarrhea.
> We did not know what antibiotic to give.
> OLPC could use MATLAB software to integrate DNA array results to
> diagnosis.
> An expert system similar to Mycin could then be used to diagnose
> disease in the field via the web.
> http://en.wikipedia.org/wiki/Mycin
Creating new software to read and analyze DNA microarrays is not hard.
MATLAB is not required. If you can make the case for microarray
analysis, appropriate software can be created easily enough.
reading a microarray typically requires a high-resolution
digital fluorescence microscope, which is very expensive
However, . Therefore,
any clinic that can make use of this technology is likely to be able to
afford more appropriate dedicated computing hardware than the XO.
--Ben Schwartz
______________________________________________________________________
This inbound email has been scanned by the MessageLabs Email Security Sys=
tem.
______________________________________________________________________
Confidentiality Notice: This e-mail, including all attachments is for the=
sole use of the intended recipient(s) and may contain confidential and p=
rivileged information. Any unauthorized review, use, disclosure or distri=
bution is prohibited unless specifically provided under the New Mexico In=
spection of Public Records Act. If you are not the intended recipient, pl=
ease contact the sender and destroy all copies of this message. -- This e=
mail has been scanned by the Sybari - Antigen Email System.=20
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charset="iso-8859-1"
Content-Transfer-Encoding: quoted-printable
<META HTTP-EQUIV=3D"Content-Type" CONTENT=3D"text/html; charset=3Diso-885=
9-1">=0A=0A<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 3.2//EN">=0A<HTML>=0A<=
HEAD>=0A=0A<META NAME=3D"Generator" CONTENT=3D"MS Exchange Server version=
6.5.7234.20">=0A<TITLE>Re: [OLPC library] 'OLPC-Health' takes off !!- MA=
TLAB for OLPC?</TITLE>=0A</HEAD>=0A<BODY>=0A<DIV id=3DidOWAReplyText89570=
dir=3Dltr>=0A<DIV dir=3Dltr><FONT color=3D#000000 size=3D2>From Ben Schw=
artz:</FONT></DIV>=0A<DIV dir=3Dltr><FONT color=3D#000000 size=3D2>"readi=
ng a microarray typically requires =0Aa high-resolution<BR>digital fluore=
scence microscope, which is very =0Aexpensive"</FONT></DIV>=0A<DIV dir=3D=
ltr><FONT size=3D2></FONT> </DIV>=0A<DIV dir=3Dltr><FONT size=3D2></=
FONT> </DIV>=0A<DIV dir=3Dltr><FONT face=3DArial color=3D#000000 siz=
e=3D2>OLPC could be connected to =0AUSB chip for fast/cheap diagnostics.<=
/FONT></DIV>=0A<DIV dir=3Dltr><FONT face=3DArial size=3D2></FONT> </=
DIV>=0A<DIV dir=3Dltr><FONT face=3DArial color=3D#000000 size=3D2><A =0Ah=
ref=3D"http://www.ece.ualberta.ca/~chrisb/research/lifesciencemain.htm">h=
ttp://www.ece.ualberta.ca/~chrisb/research/lifesciencemain.htm</A></FONT>=
</DIV>=0A<DIV dir=3Dltr><FONT face=3DArial color=3D#000000 size=3D2>Janua=
ry 29, 2008</DIV>=0A<DIV class=3D"post hentry" id=3Dpost-12698091669=
70516592 dir=3Dltr><A =0Aname=3D1269809166970516592></A>=0A<H3 class=3D"p=
ost-title entry-title"><A =0Ahref=3D"http://nextbigfuture.com/2008/01/gen=
etic-testing-lab-on-chip-for-100.html">Genetic =0Atesting Lab on a chip f=
or less than $100 Canadian</A> </H3>=0A<DIV class=3Dpost-header-line-1></=
DIV>=0A<DIV class=3D"post-body entry-content">=0A<STYLE>#fullpost {displa=
y:none;}</STYLE>=0A=0A<P><A href=3D"http://www.eurekalert.org/pub_release=
s/2008-01/uoa-loa012808.php" =0Atarget=3Dblank><FONT color=3D#5588aa>Sinc=
e a journal article was submitted to the =0ARoyal Society of Chemistry, t=
he U of Alberta researchers have already made the =0Aprocessor and unit s=
maller and have brought the cost of building <STRONG>a =0Aportable unit f=
or genetic testing</STRONG> <STRONG>down to about $100 =0ACdn</STRONG>.</=
FONT></A> In addition, these systems are also portable and even =0Afaster=
(they take only minutes). Backhouse, Elliott and McMullin are <STRONG>no=
w =0Ademonstrating prototypes of a USB key-like system </STRONG>that may =
ultimately =0Abe as inexpensive as standard USB memory keys that are in c=
ommon use – =0A<STRONG>only tens of dollars</STRONG>. It could help=
with Pandemic disease =0Acontrol and detecting and controlling tainted w=
ater supplies.<BR><BR>This =0Adevelopment fits in with my belief that the=
re should be <A =0Ahref=3D"http://nextbigfuture.com/2007/11/proposal-for-=
widespread-monitoring-and_09.html" =0Atarget=3Dblank><FONT color=3D#5588a=
a>widespread inexpensive blood, biomarker and =0Agenetic tests</FONT></A>=
to help catch disease early and to develop an =0Aunderstanding of biomar=
ker changes to track disease and aging development. <A =0Ahref=3D"http://=
nextbigfuture.com/2007/12/biomarkers-and-adaptive-clinical-trials.html" =0A=
target=3Dblank><FONT color=3D#5588aa>We can also create adaptive clinical=
trials to =0Ashorten the development and approval process for new medica=
l =0Aprocedures</FONT></A><BR><BR><FONT color=3D#5588aa><IMG =0Asrc=3D"ht=
tp://farm3.static.flickr.com/2223/2229764522_94fe125b9e.jpg?v=3D0"><BR></=
FONT>The =0Adevice is now much smaller than size of a shoe-box (USB stick=
size) with the =0Aoptics and supporting electronics filling the space ar=
ound the microchip<BR><BR>=0A<BLOCKQUOTE>Canadian scientists have <A =0A =
href=3D"http://www.rsc.org/Publishing/ChemScience/Volume/2008/02/Genetic=
_testing_shoe-box.asp" =0A target=3Dblank><FONT color=3D#5588aa>succeede=
d in building the least expensive =0A portable device for rapid genetic =
testing ever made</FONT></A>. The cost of =0A carrying out a single gene=
tic test currently varies from hundreds to thousands =0A of pounds, and =
the wait for results can take weeks. Now a group led by <A =0A href=3D"h=
ttp://www.ece.ualberta.ca/~chrisb/" target=3Dblank><FONT =0A color=3D#55=
88aa>Christopher Backhouse</FONT></A>, University of Alberta, =0A Edmont=
on, have developed a reusable microchip-based system that costs just 500 =
=0A (pounds) to build, is small enough to be portable, and can be used f=
or =0A point-of-care medical testing. <BR><BR>To keep costs down, 'inste=
ad of using =0A the very expensive confocal optics systems currently use=
d in these types of =0A devices we used a consumer-grade digital camera'=
, Backhouse explained. =0A <BR><BR>The device can be adapted for used in=
many different genetic tests. =0A 'By making small changes to the syste=
m you could test for a person's =0A predisposition to cancer, carry out =
pharmacogenetic tests for adverse drug =0A reactions or even test for pa=
thogens in a water supply,' said =0ABackhouse.</BLOCKQUOTE></DIV></DIV></=
FONT>=0A<DIV dir=3Dltr><FONT face=3DArial color=3D#000000 size=3D2>=0A<BL=
OCKQUOTE>The heart of the unit, the ‘chip,’ looks like a stan=
dard =0A microscope slide etched with fine silver and gold lines. That m=
icrofabricated =0A chip applies nano-biotechnologies within tiny volumes=
, sometimes working with =0A only a few molecules of sample. Because of =
this highly integrated chip =0A (containing microfluidics and microscale=
devices), the remainder of the system =0A is inexpensive ($1,000) and f=
ast.<BR><BR>There are many possible uses for such =0A a portable genetic=
testing unit: <BR><BR>Backhouse notes that adverse drug =0A reactions a=
re a major problem in health care. By running a quick genetic test =0A o=
n a cancer patient, for example, doctors might pinpoint the type of cance=
r =0A and determine the best drug and correct dosage for the individual.=
<BR><BR>Or =0A health-care professionals can easily look for the geneti=
c signature for a =0A virus or E. coli – also making it useful for=
testing water quality. =0A <BR><BR>“From a public health point of=
view, it would be wonderful during an =0A epidemic to be able to do a q=
uick test on a patient when they walk into an =0A emergency room and be =
able to say, ‘you have SARS, you need to go into that =0A (isolati=
on) room immediately.’ ” <BR><BR>A family doctor might determ=
ine a =0A person’s genetic predisposition to an illness during an =
office visit and =0A advise the patient on preventative lifestyle =0Acha=
nges.</BLOCKQUOTE><BR></FONT></DIV></DIV>=0A<DIV id=3DidSignature23991 di=
r=3Dltr>=0A<DIV><FONT face=3DArial color=3D#000000 size=3D2>Henry Brown</=
FONT></DIV>=0A<DIV><FONT face=3DArial size=3D2><A =0Ahref=3D"mailto:henry=
=2Ebrown at state.nm.us">henry.brown at state.nm.us</FONT><FONT =0Aface=3DArial=
size=3D2><SPAN =0Astyle=3D"FONT-SIZE: 10pt; FONT-FAMILY: Arial"></SPAN><=
/FONT></A></DIV>=0A<DIV><FONT face=3DArial size=3D2><SPAN =0Astyle=3D"FON=
T-SIZE: 10pt; FONT-FAMILY: Arial">cell 795-3680</SPAN></FONT></DIV>=0A<DI=
V><FONT face=3DArial size=3D2><SPAN =0Astyle=3D"FONT-SIZE: 10pt; FONT-FAM=
ILY: Arial">office </SPAN></FONT><FONT =0Aface=3DArial size=3D2>505 827-2=
509</FONT></DIV></DIV>=0A<DIV dir=3Dltr><BR>=0A<HR tabIndex=3D-1>=0A<FONT=
face=3DTahoma size=3D2><B>From:</B> Brown, Henry, DoIT<BR><B>Sent:</B> M=
on =0A1/28/2008 11:26 AM<BR><B>To:</B> Benjamin M. Schwartz<BR><B>Subject=
:</B> RE: =0A[OLPC library] 'OLPC-Health' takes off !!- MATLAB for OLPC?<=
BR></FONT><BR></DIV>=0A<DIV>=0A<DIV id=3DidOWAReplyText86201 dir=3Dltr>=0A=
<DIV dir=3Dltr><FONT face=3DArial color=3D#000000 size=3D2>Cheap CMOS CCD=
technology =0Aused in digital cameras may be able replace microscop=
es in the near =0Afuture.</FONT></DIV>=0A<DIV dir=3Dltr><FONT face=3DAria=
l size=3D2><A =0Ahref=3D"http://www.genewave.com/documents/PS004-03_Ampli=
ReaderW.pdf?PHPSESSID=3D1e778bdb95bb62afeb3343f27ff1b428">http://www.gene=
wave.com/documents/PS004-03_AmpliReaderW.pdf?PHPSESSID=3D1e778bdb95bb62af=
eb3343f27ff1b428</A></FONT></DIV>=0A<DIV dir=3Dltr><FONT face=3DArial siz=
e=3D2></FONT> </DIV>=0A<DIV dir=3Dltr><FONT face=3DArial size=3D2>We=
need a prototype for clinics in the =0Afield. How soon?</FONT></DIV>=0A<=
DIV dir=3Dltr><FONT face=3DArial size=3D2>There is little economic incent=
ive to =0Adevelop this technology in developing markets.</FONT></DIV>=0A<=
DIV dir=3Dltr><FONT face=3DArial size=3D2>However China and India are dev=
eloping =0Asimilar technology to cut health costs.</FONT></DIV>=0A<DIV di=
r=3Dltr><A =0Ahref=3D"http://www.sciencedaily.com/releases/2007/03/070330=
092822.htm">http://www.sciencedaily.com/releases/2007/03/070330092822.htm=
</A></DIV>=0A<DIV dir=3Dltr><FONT face=3DArial color=3D#000000 size=3D2><=
/FONT> </DIV></DIV>=0A<DIV id=3DidSignature17869 dir=3Dltr>=0A<DIV><=
FONT face=3DArial color=3D#000000 size=3D2>Henry Brown</FONT></DIV>=0A<DI=
V><FONT face=3DArial size=3D2><A =0Ahref=3D"mailto:henry.brown at state.nm.u=
s">henry.brown at state.nm.us</FONT><FONT =0Aface=3DArial size=3D2><SPAN =0A=
style=3D"FONT-SIZE: 10pt; FONT-FAMILY: Arial"></SPAN></FONT></A></DIV>=0A=
<DIV><FONT face=3DArial size=3D2><SPAN =0Astyle=3D"FONT-SIZE: 10pt; FONT-=
FAMILY: Arial">cell 795-3680</SPAN></FONT></DIV>=0A<DIV><FONT face=3DAria=
l size=3D2><SPAN =0Astyle=3D"FONT-SIZE: 10pt; FONT-FAMILY: Arial">office =
</SPAN></FONT><FONT =0Aface=3DArial size=3D2>505 827-2509</FONT></DIV></D=
IV>=0A<DIV dir=3Dltr><BR>=0A<HR tabIndex=3D-1>=0A<FONT face=3DTahoma size=
=3D2><B>From:</B> Benjamin M. Schwartz =0A[mailto:bmschwar at fas.harvard.ed=
u]<BR><B>Sent:</B> Mon 1/28/2008 11:00 =0AAM<BR><B>To:</B> Brown, Henry, =
DoIT<BR><B>Cc:</B> Arjun Sarwal; =0Alibrary at lists.laptop.org; devel at lists=
=2Elaptop.org; ehong at mathworks.com; =0Apbaca at sfccnm.edu; acpceo at yahoo.com=
<BR><B>Subject:</B> Re: [OLPC library] =0A'OLPC-Health' takes off !!- MAT=
LAB for OLPC?<BR></FONT><BR></DIV>=0A<DIV>=0A<P><FONT size=3D2>On Mon, 20=
08-01-28 at 08:34 -0700, Brown, Henry, DoIT =0Awrote:<BR><BR>> Could M=
atlab create Greene Chip DNA microarray software to =0Arun on<BR>> OLP=
C?<BR>> <A =0Ahref=3D"http://www.mailman.hs.columbia.edu/news/Lipkin_G=
reeneChip.html">http://www.mailman.hs.columbia.edu/news/Lipkin_GreeneChip=
=2Ehtml</A><BR>> =0A<A =0Ahref=3D"http://www.mathworks.com/matlabcentr=
al/fileexchange/loadFile.do?objectId=3D2573">http://www.mathworks.com/mat=
labcentral/fileexchange/loadFile.do?objectId=3D2573</A><BR>> =0A<A hre=
f=3D"http://laptop.org/">http://laptop.org/</A><BR>> <A =0Ahref=3D"htt=
p://www.sciencedaily.com/releases/2008/01/080121100909.htm">http://www.sc=
iencedaily.com/releases/2008/01/080121100909.htm</A><BR>> <BR>>=
; =0AIf the MATLAB software could run on OLPC it could be used to monitor=
<BR>> =0Adisease in the field.<BR>> I worked with AIDS patients and=
child nutrition =0Aprograms while in the<BR>> Peace Corps.<BR>> We=
saw kids die every week =0Afrom RSV and dehydration caused by<BR>> di=
arrhea.<BR>> We did not know =0Awhat antibiotic to give.<BR>> OLPC =
could use MATLAB software to integrate DNA =0Aarray results to<BR>> di=
agnosis.<BR>> An expert system similar to Mycin =0Acould then be used =
to diagnose<BR>> disease in the field via the web.<BR>> =0A<A =0Ahr=
ef=3D"http://en.wikipedia.org/wiki/Mycin">http://en.wikipedia.org/wiki/My=
cin</A><BR><BR>Creating =0Anew software to read and analyze DNA microarra=
ys is not hard.<BR>MATLAB is not =0Arequired. If you can make the c=
ase for microarray<BR>analysis, appropriate =0Asoftware can be created ea=
sily enough.<BR>reading a microarray typically =0Arequires a high-resolut=
ion<BR>digital fluorescence microscope, which is very =0Aexpensive<BR>How=
ever, . Therefore,<BR>any clinic that can make use of this =0Atechn=
ology is likely to be able to<BR>afford more appropriate dedicated =0Acom=
puting hardware than the XO.<BR><BR>--Ben =0ASchwartz<BR><BR><BR><BR>____=
__________________________________________________________________<BR>Thi=
s =0Ainbound email has been scanned by the MessageLabs Email Security =0A=
System.<BR>______________________________________________________________=
________<BR></FONT></P></DIV></DIV>=0A=0A<br><br>Confidentiality Notice: =
This e-mail, including all attachments is for the sole use of the intende=
d recipient(s) and may contain confidential and privileged information. A=
ny unauthorized review, use, disclosure or distribution is prohibited unl=
ess specifically provided under the New Mexico Inspection of Public Recor=
ds Act. If you are not the intended recipient, please contact the sender =
and destroy all copies of this message. -- This email has been scanned by=
the Sybari - Antigen Email System. <br><br><br></BODY>=0A</HTML>
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